Article
A methyl transferase links the circadian clock to the regulation of alternative splicing.
Nature - 4 Nov 2010
Sanchez Sabrina E, Petrillo Ezequiel, Beckwith Esteban J, Zhang Xu, Rugnone Matias L, Hernando C Esteban, Cuevas Juan C, Godoy Herz Micaela A, Depetris-Chauvin Ana, Simpson Craig G, Brown John W S, Cerdán Pablo D, Borevitz Justin O, Mas Paloma, Ceriani M Fernanda, Kornblihtt Alberto R, Yanovsky Marcelo J
Abstract excerpt
Circadian rhythms allow organisms to time biological processes to the most appropriate phases of the day-night cycle. Post-transcriptional regulation is emerging as an important component of circadian networks, but the molecular mechanisms linking the circadian clock to the control of RNA processing are largely unknown. Here we show that PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5), which transfers methyl groups...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.