Article

GO: A functional reporter system to identify and enrich base editing activity

2019-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Base editing (BE) is a powerful tool for engineering single nucleotide variants (SNVs) and has been used to create targeted mutations in cell lines, organoids, and animal models. Recent development of new BE enzymes has provided an extensive toolkit for genome modification; however, identifying and isolating edited cells for analysis has proven challenging. Here we report a “Gene On” (GO) report...

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Literature Corpus work: 10f6c26b-2c7d-5e88-8707-ed500a9732cc
DOI: 10.1101/862458

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