Article

Identification of Raptor and GLI1 as USP37 substrates highlight its context-specific function in medulloblastoma cells

2025-04-28

Abstract excerpt

USP37 gene encodes a deubiquitylase (DUB), which catalyzes the proteolytic removal of ubiquitin moieties from proteins to modulate their stability, cellular localization or activity. Its expression is downregulated in a subgroup of medulloblastomas driven by constitutive activation of sonic hedgehog (SHH) signaling. Patients with SHH-driven medulloblastomas with elevated expression of the RE1 silencing transcript...

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Literature Corpus work: 10e533a2-d192-5f94-a519-d5cf9fdc364f
DOI: 10.1101/2025.04.22.650057

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