Article
Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.
Cell reports - 10 Jul 2018
Akgül Seçkin, Li Yinghua, Zheng Siyuan, Kool Marcel, Treisman Daniel M, Li Chaoyang, Wang Yuan, Gröbner Susanne, Ikenoue Tsuneo, Shen Yiping, Camelo-Piragua Sandra, Tomasek Gerald, Stark Sebastian, Guduguntla Vinay, Gusella James F, Guan Kun-Liang, Pfister Stefan M, Verhaak Roel G W, Zhu Yuan
Abstract excerpt
Most human cancers arise from stem and progenitor cells by the sequential accumulation of genetic and epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here, we show that a single p53 mutation, despite causing no defect in the mouse brain, promoted neural stem and progenitor cells to spontaneously accumulate oncogenic alterations, including loss of multiple...
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