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The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ

5 Aug 2022

Abstract excerpt

Dysregulated abundance, location and transcriptional output of Hippo signaling effector TAZ have been increasingly linked to human cancers including head neck squamous cell carcinoma (HNSCC). TAZ is subjected to ubiquitination and degradation mediated by E3 ligase β-TRCP. However, the deubiquitinating enzymes and mechanisms responsible for its protein stability remain underexplored. Here, we exploited customized...

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PMID: 35931679
DOI: 10.1038/s41419-022-05113-z

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