Article

Deubiquitinase USP9X loss Sensitizes Cancer Cells to mTOR Inhibitors through p62 Dysregulation

2021-09-28

Abstract excerpt

<h4>Background: </h4> Mutations in MTOR and TSC1/2 can only explain part of variability in mTOR inhibitor response. Here, we performed a comprehensive molecular characterization of tumors with high sensitivity to these drugs to uncover novel mechanisms of response.MethodsChromophobe renal cell carcinoma (chRCC) tumors were analyzed by whole-exome sequencing. Rapamycin sensitivity, expression of mTOR pathway effect...

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Literature Corpus work: e8bae3d5-7ed4-5944-9818-1c50c7432226
DOI: 10.21203/rs.3.rs-923880/v1

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