Article
C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014
Nesti Edmund, Corson Glen M, McCleskey Maxwell, Oyer Jon A, Mandel Gail
Abstract excerpt
The repressor element 1 (RE1) silencing transcription factor (REST) in stem cells represses hundreds of genes essential to neuronal function. During neurogenesis, REST is degraded in neural progenitors to promote subsequent elaboration of a mature neuronal phenotype. Prior studies indicate that part of the degradation mechanism involves phosphorylation of two sites in the C terminus of REST that require activity...
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