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Article

Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion.

PLoS genetics - 13 Jan 2011

Ríos Yesenia, Melmed Shlomo, Lin Shuo, Liu Ning-Ai

Abstract excerpt

Loss of retinoblastoma (Rb) tumor suppressor function is associated with human malignancies. Molecular and genetic mechanisms responsible for tumorigenic Rb downregulation are not fully defined. Through a forward genetic screen and positional cloning, we identified and characterized a zebrafish ubiquitin specific peptidase 39 (usp39) mutation, the yeast and human homolog of which encodes a component of RNA...

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Identifiers

PMID: 21249182
DOI: 10.1371/journal.pgen.1001271
PMCID: PMC3020934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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