Article

mTORC1-mediated inhibition of 4EBP1 is essential for Hedgehog (HH) signaling and can be targeted to suppress HH-driven medulloblastoma

2017-04-25

Abstract excerpt

<h4>SUMMARY</h4> Mechanistic target of rapamycin (MTOR) cooperates with Hedgehog (HH) signaling, but the underlying mechanisms are incompletely understood. Here, we provide genetic, biochemical, and pharmacologic evidence that MTOR complex 1 (mTORC1)-dependent translation is a prerequisite for HH signaling. The genetic loss of mTORC1 function inhibited HH signaling– driven growth of the cerebellum and medulloblas...

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Literature Corpus work: da5c8627-27aa-5a6f-b98b-6c8672f0be97
DOI: 10.1101/130872

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