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The Mechanistic Link Between Tau-Driven Proteotoxic Stress and Cellular Senescence in Alzheimer’s Disease

2024-10-14

Abstract excerpt

In Alzheimer’s disease (AD), tau dissociates from microtubules (MTs) due to hyperphosphorylation and misfolded. It is degraded by various mechanisms, including the 20S proteasome, chaperone-mediated autophagy (CMA), 26S proteasome, macroautophagy, and aggrephagy. Neurofibrillary tangles (NFTs) form upon impairment of aggrephagy, and eventually, the ubiquitin chaperone valosin-containing protein (VCP) and heat shoc...

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Literature Corpus work
979f95db-dba2-5ac3-a0f9-4cfd06a6eefa
DOI
10.20944/preprints202410.0983.v1
Open publication

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