Article

Human tNeurons reveal aging-linked proteostasis deficits driving Alzheimer’s phenotypes

2024-05-30

Abstract excerpt

<title>Abstract</title> <p>Aging is a prominent risk factor for Alzheimer's disease (AD), but the cellular mechanisms underlying neuronal phenotypes remain elusive. Both accumulation of amyloid plaques and neurofibrillary tangles in the brain1 and age-linked organelle deficits 2-7 are proposed as causes of AD phenotypes but the relationship between these events is unclear. Here, we address this question using a t...

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Literature Corpus work: c0cdf610-bf5e-59a8-a025-9c75af353f2d
DOI: 10.21203/rs.3.rs-4407236/v1

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