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Article

Early detection of cerebral glucose uptake changes in the 5XFAD mouse.

Current Alzheimer research - 1 Jan 2014

Macdonald I R, DeBay D R, Reid G A, O'Leary T P, Jollymore C T, Mawko G, Burrell S, Martin E, Bowen C V, Brown R E, Darvesh S

Abstract excerpt

Brain glucose hypometabolism has been observed in Alzheimer's disease (AD) patients, and is detected with (18)F radiolabelled glucose, using positron emission tomography. A pathological hallmark of AD is deposition of brain β- amyloid plaques that may influence cerebral glucose metabolism. The five times familial AD (5XFAD) mouse is a model of brain amyloidosis exhibiting AD-like phenotypes. This study examines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24801216
DOI: 10.2174/1567205011666140505111354
PMCID: PMC4082185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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