Article

Neuro-Vascular-Metabolic Dysregulation, Metabolic Connectomics, and Metabolic Functional Changes in Alzheimer’s Disease: A Preclinical and Clinical Comparison

2025-11-13

Abstract excerpt

Clinical imaging diagnostics in AD primarily focus on amyloid and tau accumulation; however, recent work suggests that neuro-metabolic and vascular dysregulation (MVD) begins prior to protein deposition. MVD changes persist in preclinical and clinical cases across the disease spectrum; therefore, comparing them could provide valuable insight into disease onset and progression. Regional MVD phenotypes were determin...

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Literature Corpus work: 380bf0ac-708b-59a0-bca6-0d5e1c59104e
DOI: 10.20944/preprints202511.1035.v1

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