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Article

Cerebrovascular pathology during the progression of experimental Alzheimer's disease.

Neurobiology of disease - 1 Apr 2016

Giannoni Patrizia, Arango-Lievano Margarita, Neves Ines Das, Rousset Marie-Claude, Baranger Kévin, Rivera Santiago, Jeanneteau Freddy, Claeysen Sylvie, Marchi Nicola

Abstract excerpt

Clinical and experimental evidence point to a possible role of cerebrovascular dysfunction in Alzheimer's disease (AD). The 5xFAD mouse model of AD expresses human amyloid precursor protein and presenilin genes with mutations found in AD patients. It remains unknown whether amyloid deposition driven by these mutations is associated with cerebrovascular changes. 5xFAD and wild type mice (2 to 12months old; M2 to...

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PMID: 26774030
DOI: 10.1016/j.nbd.2016.01.001

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GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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