Article

Dysfunctional B cell and interferon signaling in autoimmune polyendocrine syndrome type 1

2022-09-16

Abstract excerpt

<title>Abstract</title> <p>Purpose: Autoimmune polyendocrine syndrome type I (APS-1) is a devastating autoimmune disease characterised by mutations in the <italic>AIRE </italic>gene. Because of failure of negative selection, these patients produce autoreactive B and T cells against affected tissues, which lead to a range of autoimmune manifestations. The rarity of APS-1 and inaccessibility of thymic tissue have l...

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Literature Corpus work: 6adc9837-dc89-5884-8190-207f756edace
DOI: 10.21203/rs.3.rs-2049437/v1

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