Article

De novo detection of somatic variants in high-quality long-read single-cell RNA sequencing data

2024-03-08

Abstract excerpt

In cancer, genetic and transcriptomic variations generate clonal heterogeneity, leading to treatment resistance. Long-read single-cell RNA sequencing (LR scRNA-seq) has the potential to detect genetic and transcriptomic variations simultaneously. Here, we present LongSom, a computational workflow leveraging high-quality LR scRNA-seq data to call de novo somatic single-nucleotide variants (SNVs), including in mitoc...

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Literature Corpus work: 0bd9e0ca-a7f2-5985-95d8-3aee6a546c33
DOI: 10.1101/2024.03.06.583775

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