Article

Analysis of RNA Exosome Subunit Transcript Abundance Across Tissues: Implications for Neurological Disease Pathogenesis

2023-06-07

Abstract excerpt

Exosomopathies are a collection of rare diseases caused by mutations in genes that encode structural subunits of a ribonuclease complex termed the RNA exosome. The RNA exosome mediates both RNA processing and degradation of multiple classes of RNA. This complex is evolutionarily conserved and required for fundamental cellular functions, including rRNA processing. Recently, missense mutations in genes encoding stru...

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Literature Corpus work: 1f7b656d-ed0e-55c7-9b7d-e09f1a789c96
DOI: 10.1101/2023.06.07.544082

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