Article

RNA exosome-mediated RNA surveillance governs developmental timing in the human cerebellum

2026-04-22

Abstract excerpt

Defects in RNA metabolism are a defining feature of neurodevelopmental disease, yet how RNA decay pathways contribute to human brain development remains poorly understood. Mutations in ubiquitously expressed RNA surveillance factors often cause highly tissue-selective disease, highlighting a central paradox in human biology. The RNA exosome is a conserved ribonuclease complex traditionally viewed as a housekeeping...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ded44606-1dad-5ebf-a516-4e39ddfd65f0
DOI: 10.64898/2026.04.19.719460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA exosome-mediated RNA surveillance governs developmental timing in the human cerebellumDOI 10.64898/2026.04.19.719460Read

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brainSemantic proximity Read

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain.Semantic proximity Read

Analysis of RNA Exosome Subunit Transcript Abundance Across Tissues: Implications for Neurological Disease PathogenesisSemantic proximity Read

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.Semantic proximity Read

RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.Semantic proximity Read

The RNA exosome and RNA exosome-linked disease.Semantic proximity Read

A <i>Drosophila</i> Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in NeuronsSemantic proximity Read

The RNA Exosome and Human Disease.Semantic proximity Read

Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy.Semantic proximity Read

EXOSC10-mediated pre-tRNA surveillance safeguards neuron survivalSemantic proximity Read

Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy.Semantic proximity Read

From Transcriptome to Therapy: The ncRNA Revolution in Neurodevelopmental DisordersSemantic proximity Read