Article

Precise engineering of chimeric antigen receptor expression levels defines T cell identity and function

2025-02-11

Abstract excerpt

Chimeric Antigen Receptor (CAR) T therapy is a potent treatment for haematological malignancies, but T cell exhaustion reduces its efficacy in many patients. Although high CAR transgene levels appear to drive T cell exhaustion, the relationship between CAR expression levels, T cell function, and transcriptional identity is yet to be mapped at high resolution. Here, we harness a high-resolution microRNA-based contr...

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Literature Corpus work: 07aece80-3792-5ec5-8e2b-ea9948ff61ff
DOI: 10.1101/2025.02.10.637482

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