Article

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

2023-11-29

Abstract excerpt

<h4>ABSTRACT</h4> The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for pathogenicity and antigenicity remain elusive. In this study, we performed a series of deep mutational scanning (DMS) experiments on an S2 region spanning th...

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Literature Corpus work: 103e6242-a528-5cf7-9ecc-6b5d2e626639
DOI: 10.1101/2023.11.28.569051

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