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Article

Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease.

mBio - 30 Aug 2022

Stevaert Annelies, Van Berwaer Ria, Mestdagh Cato, Vandeput Julie, Vanstreels Els, Raeymaekers Valerie, Laporte Manon, Naesens Lieve

Abstract excerpt

The continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urges better understanding of the functional motifs in the spike (S) protein and their tolerance to mutations. Here, we focused on the S2' motif, which, during virus entry, requires cleavage by a host cell protease to release the fusion peptide. Though belonging to an immunogenic region, the SARS-CoV-2 S2'...

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Identifiers

PMID: 35913162
DOI: 10.1128/mbio.01376-22
PMCID: PMC9426466

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