Article

Effect of SARS-CoV-2 spike mutations on its activation by TMPRSS2 and TMPRSS13

2022-01-27

Abstract excerpt

<h4>ABSTRACT</h4> The continuous emergence of new SARS-CoV-2 variants urges better understanding of the functional motifs in the spike (S) protein and their tolerance towards mutations. We here focus on the S2’ motif which, during virus entry, requires cleavage by a cell surface protease to release the fusion peptide. Though belonging to an immunogenic region, the SARS-CoV-2 S2’ motif (811-KPSKR-815) has shown ha...

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Literature Corpus work: ef21de6d-337f-5bcc-9a10-f70477020f5b
DOI: 10.1101/2022.01.26.477969

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