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Article

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning.

Nature communications - 14 May 2024

Lei Ruipeng, Qing Enya, Odle Abby, Yuan Meng, Gunawardene Chaminda D, Tan Timothy J C, So Natalie, Ouyang Wenhao O, Wilson Ian A, Gallagher Tom, Perlman Stanley, Wu Nicholas C, Wong Lok-Yin Roy

Abstract excerpt

The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for pathogenicity and antigenicity remain elusive. In this study, we perform a series of deep mutational scanning (DMS) experiments on an S2 region spanning the fusion peptide of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38744813
DOI: 10.1038/s41467-024-48104-8
PMCID: PMC11094058

Genes

TMPRSS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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