Article

Scaled and Efficient Derivation of Loss of Function Alleles in Risk Genes for Neurodevelopmental and Psychiatric Disorders in Human iPSC

2024-03-19

Abstract excerpt

<h4>Summary</h4> Translating genetic findings for neurodevelopmental and psychiatric disorders (NPD) into actionable disease biology would benefit from large-scale and unbiased functional studies of NPD genes. Leveraging the cytosine base editing (CBE) system, here we developed a pipeline for clonal loss-of-function (LoF) allele mutagenesis in human induced pluripotent stem cells (hiPSCs) by introducing premature...

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Literature Corpus work: 1012d5b7-efb6-5de8-ba40-7b00215d6ef4
DOI: 10.1101/2024.03.18.585542

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