Article

Effects of somatic mutations on cellular differentiation in iPSC models of neurodevelopment

2022-03-04

Abstract excerpt

The use of induced pluripotent stem cells (iPSC) as models for development and human disease has enabled the study of otherwise inaccessible tissues. A remaining challenge in developing reliable models is our limited understanding of the factors driving irregular in vitro differentiation of iPSCs, particularly the impact of acquired somatic mutations. We leveraged data from a pooled dopaminergic neuron differenti...

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Literature Corpus work: fdfcf425-a86a-5d49-b074-40c678729048
DOI: 10.1101/2022.03.04.482992

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