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<i>DPYSL2</i> / <i>CRMP2</i> isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders

2022-11-19

Abstract excerpt

<h4>ABSTRACT</h4> DPYSL2/CRMP2 is a microtubule-stabilizing protein crucial for neurogenesis and associated with numerous psychiatric and neurodegenerative disorders. DPYSL2 has multiple RNA and protein isoforms, but few studies have differentiated between them or explored their individual functions. We previously demonstrated in HEK293 cells that a schizophrenia -associated variant in the DPYSL2 B isoform ( D...

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Literature Corpus work
80e618b3-08e9-5021-aa8d-b785017d73d2
DOI
10.1101/2022.11.19.517191
Open publication

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<i>DPYSL2</i> / <i>CRMP2</i> isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disordersDOI 10.1101/2022.11.19.517191
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