Surrogate selection oversamples expanded T cell clonotypes

Abstract excerpt

Inference from immunological data on cells in the adaptive immune system may benefit from modeling specifications that describe variation in the sizes of various clonal sub-populations. We develop one such specification in order to quantify the effects of surrogate selection assays, which we confirm may lead to an enrichment for amplified, potentially disease-relevant T cell clones. Our specification couples withi...

Topics

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• Clonal Evolution
• Cluster Analysis
• Genetic Variation
• Lymphocytes
• Models, Immunological
• Receptors, Antigen
• Support Vector Machine
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

0fef39c8-a180-5b49-8ec4-f8a5a4ef1520

DOI

10.1101/2023.07.13.548950