How many different clonotypes do immune repertoires contain?

Abstract excerpt

Immune repertoires rely on diversity of T-cell receptors and immunoglobulins to protect us against foreign threats. The ability to recognize a wide variety of pathogens is linked to the number of different clonotypes expressed by an individual. Out of the estimated ∼1012 different B and T cells in humans, how many of them express distinct receptors? We review current and past estimates for these numbers. We point...

Topics

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• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

5673bdd3-173d-5cd0-9b40-2c5c84d7e1c9

DOI

10.1016/j.coisb.2019.10.001