Article
Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution.
Immunology letters - 1 Jan 2000
Mehr Ramit, Sternberg-Simon Michal, Michaeli Miri, Pickman Yishai
Abstract excerpt
T and B cell receptor repertoires are diversified by variable region gene rearrangement and selected based on functionality and lack of self-reactivity. Repertoires can also be defined based on phenotype and function rather than receptor specificity - such as the diversity of T helper cell subsets. Natural killer (NK) cell repertoires, in which each cell expresses a randomly chosen subset of its inhibitory...
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