Article

Cryo-EM structure of human LRRC15 reveals the basis of therapeutic antibody recognition

2026-06-18

Abstract excerpt

Leucine-rich repeat containing 15 (LRRC15) is a structural uncharacterised membrane protein, which is highly upregulated in cancer-associated fibroblasts and enriched in desmoplastic tumours including pancreatic, breast and head-and-neck cancers, where it is associated with therapy resistance. The LRRC15-targeting antibody-drug conjugate samrotamab vedotin has advanced into Phase I clinical evaluation, yet mechani...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0fca149a-911f-5bf9-b43c-8d48e01cfa83
DOI: 10.64898/2026.06.16.732218

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cryo-EM structure of human LRRC15 reveals the basis of therapeutic antibody recognitionDOI 10.64898/2026.06.16.732218Read

Development of a LRRC15-Targeted Radio-Immunotheranostic Approach to Deplete Pro-tumorigenic Mechanisms and Immunotherapy ResistanceSemantic proximity Read

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1Semantic proximity Read

Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeuticsSemantic proximity Read

Deep mutational scanning reveals transmembrane features governing surface expression of the B cell antigen receptor.Semantic proximity Read

Structural analysis of tilvestamab in complex with AXLSemantic proximity Read

Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel “Achilles heel” for therapeutic interventionSemantic proximity Read

Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3Semantic proximity Read

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1Semantic proximity Read

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81.Semantic proximity Read

A Computational Foundation Toward Targeting the ELMO1/DOCK2 ComplexSemantic proximity Read

Two helices control the dynamic crosstalk between the catalytic domains of LRRK2Semantic proximity Read

Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3Semantic proximity Read