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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

8 Sept 2022

Abstract excerpt

Enteroviruses cause a number of medically relevant and widespread human diseases with no approved antiviral therapies currently available. Host-directed therapies present an enticing option for this diverse genus of viruses. We have previously identified the actin histidine methyltransferase SETD3 as a critical host factor physically interacting with the viral protease 2A. Here, we report the 3.5 Å cryo-EM...

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PMID: 36075902
DOI: 10.1038/s41467-022-32758-3

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