Article

Structures of bacterial and human phosphoglycosyltransferases bound to a common inhibitor inform selective therapeutics

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> Glycoconjugates facilitate myriad biological processes, including cell–cell recognition and immune response, and they are generated by enzymes that transfer glycans. The orthologs MraY and DPAGT1 are dimeric phosphoglycosyltransferases involved in oligosaccharide biosynthesis for either bacterial peptidoglycan or eukaryotic N -linked glycans, respectively. Both enzymes play central regulatory r...

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Literature Corpus work: 6e6e87e6-b934-5c88-99f3-dec465996fce
DOI: 10.64898/2025.12.16.694696

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