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Article

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81.

Science (New York, N.Y.) - 15 Jan 2021

Susa Katherine J, Rawson Shaun, Kruse Andrew C, Blacklow Stephen C

Abstract excerpt

Signaling through the CD19-CD81 co-receptor complex, in combination with the B cell receptor, is a critical determinant of B cell development and activation. It is unknown how CD81 engages CD19 to enable co-receptor function. Here, we report a 3.8-angstrom structure of the CD19-CD81 complex bound to a therapeutic antigen-binding fragment, determined by cryo-electron microscopy (cryo-EM). The structure includes...

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Share to Cryoelectron Microscopy
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, CD19

Share to B-Lymphocytes

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Share to Receptors, Antigen, B-Cell

Share to Tetraspanin 28

Source

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Identifiers

PMID: 33446559
DOI: 10.1126/science.abd9836
PMCID: PMC8111558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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