Article

Structural analysis of tilvestamab in complex with AXL

2024-12-04

Abstract excerpt

AXL is a receptor tyrosine kinase with a significant role in various biological processes and important medical implications, particularly in cancer. AXL transduces signals from the extracellular environment into the cytoplasm by binding to its ligand, growth arrest-specific protein 6 (GAS6). Activation of AXL leads to autophosphorylation of its intracellular domain and subsequent activation of downstream signalin...

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Literature Corpus work: e25fb9d8-1f69-569a-a9b1-65b4479dc7fb
DOI: 10.1101/2024.12.04.626834

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