Article

Structure and function of human NXPE1, a sialic acid <i>O</i> -acetyltransferase

2026-05-22

Abstract excerpt

Human genetic studies have identified defects in multiple mechanisms that predispose the risk of developing inflammatory bowel diseases (IBD), which include alterations in adaptive and innate immune responses, epithelial integrity and regulation of the intestinal mucus layer. Despite the importance of intestinal barrier integrity in the pathogenesis of IBD, essentially all current therapies modulate the immune res...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f956ece-edb4-5e30-9829-1a4f23c024b0
DOI: 10.64898/2026.05.20.726592

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure and function of human NXPE1, a sialic acid <i>O</i> -acetyltransferaseDOI 10.64898/2026.05.20.726592Read

The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic MucinSemantic proximity Read

<i>NXPE1</i>alters the sialoglycome by acetylating sialic acids in the human colonSemantic proximity Read

Intestinal epithelial <i>Casd1</i> influences mucus sialic acid <i>O-</i> acetylation and tissue damage susceptibility toward large-intestinal mucosal insultsSemantic proximity Read

Arthritis-Associated Inflammation Remodels Colonic O-GlycosylationSemantic proximity Read

N-glycosylation enzyme Mpi is essential for mucin O-glycosylation, host-microbe homeostasis, Paneth cell defense, and metabolismSemantic proximity Read

Mucin function in inflammatory bowel disease: an update.Semantic proximity Read

Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseasesSemantic proximity Read

NINJ1 plays a vital role in the release of neutrophil extracellular traps in acute lung injurySemantic proximity Read

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevitySemantic proximity Read

O-acetylated Gangliosides as Targets for Cancer ImmunotherapySemantic proximity Read

Axin1‘s mystique in manipulating microbiome amidst colitisSemantic proximity Read

Lysine acetylation of NKG2D ligand Rae-1 stabilizes the protein and sensitizes tumor cells to NKG2D immune surveillance.Semantic proximity Read