Back to search

Article

Intestinal epithelial <i>Casd1</i> influences mucus sialic acid <i>O-</i> acetylation and tissue damage susceptibility toward large-intestinal mucosal insults

2026-02-09

Abstract excerpt

<h4>ABSTRACT</h4> The intestinal mucus network, primarily composed of O -glycosylated MUC2 mucin polymers, is essential for protecting the gastrointestinal tract from microbial threats. Sialic acid (Sia), a terminal monosaccharide on complex O -glycans, plays a key role in maintaining mucus integrity and is frequently modified by Casd1-dependent O -acetylation ( O Ac). Despite its prevalence, the biological s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e9c2ba29-ff87-50b2-9c31-07cab5e58306
DOI
10.64898/2026.02.07.702670
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Intestinal epithelial <i>Casd1</i> influences mucus sialic acid <i>O-</i> acetylation and tissue damage susceptibility toward large-intestinal mucosal insultsDOI 10.64898/2026.02.07.702670
Sialylation shapes mucus architecture inhibiting bacterial invasion in the colonSemantic proximity
The immune interactions of gut glycans and microbiota in health and diseaseSemantic proximity
The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic MucinSemantic proximity
N-glycosylation enzyme Mpi is essential for mucin O-glycosylation, host-microbe homeostasis, Paneth cell defense, and metabolismSemantic proximity
Bacterial Colonization and TH17 Immunity are Shaped by Intestinal Sialylation in Neonatal MiceSemantic proximity
Mucin-derived <i>O</i> -glycans supplemented to diet mitigate diverse microbiota perturbationsSemantic proximity
Alterations in mucosa branched N -glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammationSemantic proximity
Arthritis-Associated Inflammation Remodels Colonic O-GlycosylationSemantic proximity
Structure and function of human NXPE1, a sialic acid <i>O</i> -acetyltransferaseSemantic proximity
Mucins Dynamics in Physiological and Pathological ConditionsSemantic proximity
Loss of intestinal O-glycans promotes spontaneous duodenal tumors.Semantic proximity
Mucin function in inflammatory bowel disease: an update.Semantic proximity
Select a neighboring publication to make it the new centre.