Article

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

2022-09-02

Abstract excerpt

<h4>SUMMARY</h4> Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal acetyltransferase and specific ubiquitin ligases. Biochemical analyses uncover that both the ubiquitin ligase complex UBR4-KCMF1 and the acetyltransferase N...

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Literature Corpus work: 2a49dc06-ddbe-5278-8c7e-4ca00d5e04f9
DOI: 10.1101/2022.09.01.505523

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