Article

The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin

2024-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Colonic mucus forms a first line of defense against bacterial invasion while providing nutrition to support coinhabiting microbes in the gut. Mucus is composed of polymeric networks of mucin proteins, which are heavily modified post-translationally. The full compendium of enzymes responsible for these modifications and their roles in health and disease remain incompletely understood. Herein we d...

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Literature Corpus work: 6146910c-af22-5367-8d27-51c0a23c8900
DOI: 10.1101/2024.12.24.630288

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