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Article

O-acetylated Gangliosides as Targets for Cancer Immunotherapy

17 Mar 2020

Abstract excerpt

O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities. CAS1 Domain-Containing Protein 1 (CASD1) is the only human sialyl-O-acetyltransferases (SOAT) described until now. O-acetylated ganglioside species are mainly expressed during...

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PMID: 32192217
DOI: 10.3390/cells9030741

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