Article

N-glycosylation enzyme Mpi is essential for mucin O-glycosylation, host-microbe homeostasis, Paneth cell defense, and metabolism

2025-03-25

Abstract excerpt

<title>Abstract</title> Intestinal homeostasis relies on a protective mucus layer that separates bacteria from the host, with Muc2 as its primary component. This secreted, gel-forming mucin is heavily O-glycosylated, allowing it to retain water and support beneficial bacteria. For the first time, we demonstrate that Muc2 N-glycosylation plays a critical in mucin maturation, O-glycosylation, barrier integrity,...

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Literature Corpus work: 284358cd-50af-511f-a681-1b35d4e3080e
DOI: 10.21203/rs.3.rs-6222474/v1

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