Article

Construction of light-activated neurotrophin receptors using the improved Light-Induced Dimerizer (iLID)

2019-11-21

Abstract excerpt

Receptor tyrosine kinases (RTKs) play crucial roles in human health, and their misregulation is implicated in disorders ranging from neurodegenerative disorders to cancers. The highly conserved mechanism of activation of RTKs makes them especially appealing candidates for control via optogenetic dimerization methods. This work offers a strategy for using the improved Light-Induced Dimer (iLID) system with a constr...

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Literature Corpus work: 0f854e3d-2010-5ef0-a3eb-72f1938c8375
DOI: 10.1101/850412

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