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Distinct regional ontogeny and activation of tumor associated macrophages in human glioblastoma

11 Nov 2020

Abstract excerpt

Tumor-associated macrophages (TAMs) constitute up to 50% of tumor bulk in glioblastoma (GBM) and play an important role in tumor maintenance and progression. The recently discovered differences between invading tumour periphery and hypoxic tumor core implies that macrophage biology is also distinct by location. This may provide further insight into the observed treatment resistance to immune modulation. We...

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PMID: 33177572
DOI: 10.1038/s41598-020-76657-3

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