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Article

Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

Cell reports - 14 Sept 2021

Liu Hailong, Sun Youliang, Zhang Qian, Jin Wei, Gordon Renata E, Zhang Yanyang, Wang Jian, Sun Caihong, Wang Zeyuan John, Qi Xueling, Zhang Junping, Huang Boyuan, Gui Qiuping, Yuan Hongyu, Chen Ling, Ma Xiaodong, Fang Chuan, Liu Yong-Qiang, Yu Xinguang, Feng Shiyu

Abstract excerpt

Scant understanding of the glioblastoma microenvironment and molecular bases hampers development of efficient treatment strategies. Analyses of gene signatures of human gliomas demonstrate that the SETD2 mutation is correlated with poor prognosis of IDH1/2 wild-type (IDH-WT) adult glioblastoma patients. To better understand the crosstalk between SETD2 mutant (SETD2-mut) glioblastoma cells and the tumor...

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Identifiers

PMID: 34525361
DOI: 10.1016/j.celrep.2021.109718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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