Article

Intrinsic and non-cell autonomous roles for a neurodevelopmental syndrome-linked transcription factor

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factors (TFs) are essential for neuronal identity, yet their potential non–cell-autonomous functions remain largely unexplored. Here, we uncover both cell- and non–cell-autonomous roles for the conserved terminal selector UNC-3 in C. elegans motor neurons (MNs). UNC-3 is an ortholog of human EBF3, mutations in which cause a severe neurodevelopmental syndrome. Single-cell RNA seque...

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Literature Corpus work: 753df1bb-a172-5856-b028-3e32390de08f
DOI: 10.64898/2025.12.23.696256

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