Article

FACT sets a barrier for cell fate reprogramming in <i>C. elegans</i> and Human

2017-09-06

Abstract excerpt

<h4>Summary</h4> <h4>Abstract Figure</h4> The chromatin regulator FACT (Facilitates Chromatin Transcription) is essential for ensuring stable gene expression by promoting transcription. In a genetic screen using C. elegans we identified that FACT maintains cell identities and acts as a barrier for transcription factor-mediated cell fate reprogramming. Strikingly, FACT’s role as a reprogramming barrier is conser...

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Literature Corpus work: c0b308c0-7522-5fa2-bec1-c2aa43bb493f
DOI: 10.1101/185116

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