Article

A single-cell catalogue of regulatory states in the ageing <i>Drosophila</i> brain

2017-12-21

Abstract excerpt

<h4>Summary</h4> The diversity of cell types and regulatory states in the brain, and how these change during ageing, remains largely unknown. Here, we present a single-cell transcriptome catalogue of the entire adult Drosophila melanogaster brain sampled across its lifespan. Both neurons and glia age through a process of “regulatory erosion”, characterized by a strong decline of RNA content, and accompanied by i...

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Literature Corpus work: ba37059b-c8f2-5712-98e8-98129d59d3d0
DOI: 10.1101/237420

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