Article

Decreasing <i>Wapl</i> dosage partially corrects transcriptome phenotypes in <i>Nipbl</i> -/+ embryonic mouse brain

2022-06-01

Abstract excerpt

Cohesin rings interact with DNA and modulate expression of thousands of genes. NIPBL loads cohesin onto chromosomes and WAPL takes it off. Heterozygous mutations in NIPBL lead to a developmental disorder called Cornelia de Lange syndrome. Nipbl heterozygous mice are a good model for this disease but mutations in WAPL were not known to cause disease or gene expression changes in mammals. Here we show dysregulati...

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Literature Corpus work: 2fd46cef-4055-58b8-bf36-6d548d235a86
DOI: 10.1101/2022.05.31.493745

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