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Article

Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.

Development (Cambridge, England) - 1 Sept 2013

Feng Guoxin, Yi Peishan, Yang Yihong, Chai Yongping, Tian Dong, Zhu Zhiwen, Liu Jianhong, Zhou Fanli, Cheng Ze, Wang Xiangming, Li Wei, Ou Guangshuo

Abstract excerpt

Neuroblasts generate neurons with different functions by asymmetric cell division, cell cycle exit and differentiation. The underlying transcriptional regulatory pathways remain elusive. Here, we performed genetic screens in C. elegans and identified three evolutionarily conserved transcription factors (TFs) essential for Q neuroblast lineage progression. Through live cell imaging and genetic analysis, we showed...

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PMID: 23946438
DOI: 10.1242/dev.098723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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