Article

Protein aggregation of DISC1, as assayed by insolubility, varies across the brain of an individual with schizophrenia and Alzheimer’s disease

2023-08-06

Abstract excerpt

<h4>Objective</h4> Subgroups of mental illness patients have been seen to display disturbed proteostasis, with specific proteins aggregating in their brain, which is generally determined by assaying protein insolubility in the post mortem samples. Such studies typically only look at one region of the brain, and therefore we aimed to determine the distribution of protein across a single brain, using this insolubili...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f6b3071-5477-59df-8ac9-11c6465033d8
DOI: 10.1101/2023.08.01.23293413

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protein aggregation of DISC1, as assayed by insolubility, varies across the brain of an individual with schizophrenia and Alzheimer’s diseaseDOI 10.1101/2023.08.01.23293413Read

Aggregation of Disrupted in Schizophrenia 1 arises from a central region of the proteinSemantic proximity Read

Aggregated proteins in schizophrenia and other chronic mental diseasesSemantic proximity Read

Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease.Semantic proximity Read

DISCopathies: brain disorders related to DISC1 dysfunction.Semantic proximity Read

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.Semantic proximity Read

Protein Aggregation of NPAS3, Implicated in Mental Illness, Is Not Limited to the V304I MutationSemantic proximity Read

Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.Semantic proximity Read

A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuseSemantic proximity Read

Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondriaSemantic proximity Read

Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's diseaseSemantic proximity Read

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Key Regulator Unifying Neurodevelopment and Synaptic FunctionSemantic proximity Read

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.Semantic proximity Read