Article

Aggregation of Disrupted in Schizophrenia 1 arises from a central region of the protein

2023-08-04

Abstract excerpt

An emerging approach to studying major mental illness is through proteostasis, with the identification of several proteins that form insoluble aggregates in the brains of patients. One of these is Disrupted in Schizophrenia 1 (DISC1), a neurodevelopmentally-important scaffold protein, and the product of a classic schizophrenia risk gene. DISC1 was seen to aggregate in post mortem tissue from patients with schizoph...

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Literature Corpus work: 315a9cd3-0fb0-5089-8127-847cbe5708ec
DOI: 10.1101/2023.08.03.551216

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